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Energy + Mind Herb Bacopa Monnieri Considered Future Candidate for Chronic Pain Management

Coffee can help ease chronic pain? 

It can if it’s infused with Ayurvedic herb Bacopa Monnieri.

Check out this recent abstract from Current Medical Chemistry:

Chronic pain management costs billions of dollars in medical exchequer to the world population. Additionally, 77% of people with chronic pains also have a degree of medically treatable depression. Bacopa monnieri, a renowned ayurvedic medicine has a strong antidepressant effect and significant anti-nociceptive effect, which is comparable to the effect of morphine via adenosinergic, opioidergic, and adrenergic mechanisms. BM has been also reported to be effective in neuropathic pains. Additionally, it has a strong anti-inflammatory effect mediated via COX-2 inhibitory mechanism.

Apart from its effect of augmenting morphine analgesia, BM also inhibits opioid-withdrawal induced hyperalgesia, and acquisition and expression of morphine tolerance. BM is reported to have a strong protective effect against toxic effects of opiates on major organs like brain, kidneys and heart. BM is well documented to be safe and well tolerated herbal therapy in multiple clinical trials including various age groups. This mini review evaluated the preclinical data that highlights potential of BM as a future candidate for clinical management of chronic pains.

Energy + Mind White Paper

Ayurveda is a system of Hindu traditional medicine native to the Indian subcontinent that dates back over 3000 years. The origins of Ayurveda describe magical cures for disease, most including the use of herbal medicines, minerals or metal supplementation, surgical techniques, opium, and applications of oil by massages.

Although considered magical or mystical at one time, many of these therapies have been intensively studied by modern science and observed to have specific mechanisms of action in the body, confirming their benefits.

Two of these herbal remedies are among the most widely known in Ayurveda, and thus have the most scientific research behind them. They are Bacopa monnieri and Centella asiatica, also referred to as Gotu Kola. It was for these widely known and well-researched benefits that Javita utilized such powerful herbs when formulating Energy + Mind Coffee, a product designed to support brain function while improving mental energy and focus.

This white paper will walk through the history of use of these plants which lead scientists in pursuit of validation using modern research techniques. This paper will present and evaluate available research, from cellular to animal models and finally human clinical trials. A detailed description of the mechanisms by which these herbs work in the body will be discussed along with the outcomes of clinical trial. Safety will also be reviewed along with dosing recommendations for the benefits described for Energy + Mind Coffee. Any adverse events noted in clinical trials or potential negative outcomes from supplementation with these herbs will also be addressed.

Click here to review and download the Energy + Mind White Paper in its entirety.

Herbal Remedies Showing Promise for Sufferers of ADD and ADHD

Parents and professionals faced with the challenging task of treating ADD and ADHD in children commonly face an unfortunate situation in which behavior problems at home and/or school have placed yet another pressure to opt for medication as the primary treatment.

There is little doubt that the majority of these ‘medicated’ children will have benefits in their attention span, behavior, and other components of their disorder. And yet, the benefits of medication come with built-in risks from misdiagnosis, side effects, abuse, and unforeseen long-term complications.

Although complementary and alternative therapies have shown promise in treating ADD and ADHD, the task of matching the patient to the most appropriate of these therapies remains elusive to many parents who have explored the options, as well as professionals. Many treating physicians are waiting for better studies, and conventional standards, to help establish appropriate treatment protocols. The use of herbal medicine in the treatment of ADHD is of high interest to many families and professionals looking for alternatives to drug therapy. This interest has no doubt heightened in recent years due to problematic and near epidemic proportion use of stimulants in children.

The following review of an alarming trend to medicate ever-increasing numbers of school- and pre-school age children will help serve to emphasize the need for greater research into natural alternative treatments.

Conventional pharmaceutical treatment for ADD/ADHD commonly includes methylphenidate or amphetamine substances that have the highest abuse potential and dependence profile of all drugs that have medical utility. According to statistical records, the production of methylphenidate by the drug manufacturers in the world has increased by more than 500 percent since 1991. The production of amphetamine has increased by over 2,000 percent in the same nine-year period of time. More than 50 percent of the methylphenidate and amphetamine prescriptions are written by pediatricians. Ayurveda, which means “life sciences” in Sanskrit, is a holistic system of Indian medicine that evolved between 3000 and 5000 years ago. It is becoming more and more popular in the India and abroad and is still used by the majority of people in India to treat a variety of health problems, because not only is it time-tested for its safety and effectiveness, it is accessible and inexpensive.

Bacopa monniera-named Brahmi in the Ayurvedic texts, probably for Lord Brahma, the Hindu creator of the world and originator of Ayurveda-is recognized as a powerful brain enhancer.1 It is still considered to be the greatest herb in Ayurveda for treating age-related mental decline, as well as for improving cognitive processes, including comprehension, memory and recall. It also enhances the crucial coordination of these three aspects of mental functioning, and helps increase one’s ability to solve problems

Although people in India, especially ayurvedic physicians, knew about Brahmi’s benefits thousands of years ago, new research is emerging. The trails have resulted in establishing that this long treasured herb, besides possessing antioxidant properties, also has the amazing ability to facilitate learning and enhance memory and concentration.

Ayurvedic tests describe Brahmi as medhya, a medicine that braces the mind to carry cognitive functions and intellectual pursuits. But ancient authors seem to believe that the healing effects of Brahmi extend far beyond mind and brain. Brahmi is not only a memory-booster and intellect-promoting herb; it is also a muscle relaxant, an anti-convulsant, a blood purifier, and an anti-pyretic, carminative and digestive agent.

Though Brahmi is beneficial for maintaining the tridoshic balance, ayurvedic physicians believe it to be the drug of choice for counteracting the vitiated vata dosha — the factor which governs the nervous system. Brahmi is known for its salutary effect in anxiety, depression, hypertension, sleeplessness, mental retardation, insanity and hysteria.

Acharya Chakradutta has written that Brahmi is beneficial in all types of epilepsy. Ancient texts describe the use of Brahmi in a number of other disorders like biliousness, ulcers, splenomegaly, asthma, skin diseases and in general and senile debility. Brahmi enhances the mind’s ability to learn and concentrate. As it simultaneously calms and invigorates the mind, it is a very good medicine for reducing the effects of stress and nervous anxiety.

It also helps maintain the clarity of thought and has proved effective in treating ADD (Attention Deficit Disorder) in hyperactive children, and age-related mental disorders in old persons.

In a double-blind, randomized trial conducted at the Department of Pediatrics, BRD Medical College, Gorakhpur, India, 19 ADHD children, aged 8-10 years old, were given 50 mg. of Bacopa twice daily. 17 ADHD children received a placebo. After 12 weeks of treatment, the children took a battery of specialized tests. The data revealed a significant improvement in the areas of sentence repetition, logical memory, and pair-associative learning (matching things that go together; e.g., “test” and “grade”) in all 19 children who took Bacopa. Evaluation did not occur until four weeks after stopping Bacopa usage, indicating that it had a lasting effect.5

Now, thanks to this study and other numerous studies conducted by the Central Drug Institute (CDRI) in Lucknow, India, it is being introduced to the rest of the world and tested by scientists outside of India, who have found that Bacopa:

  • Increases mental agility and alertness
  • Improves memory
  • Increases ability to learn new information and skills
  • Calms the mind, while promoting relaxation
  • Improves academic performance
  • Helps concentration and focus

According to scientists at the CDRI, a number of compounds have been identified in Bacopa, including bacosides A and B, two chemicals that improve the transmission of impulses between nerve cells in the brain. These bacosides regenerate synapses and repair damaged neurons, making it easier to learn and remember new information. Bacopa also increases serotonin levels, a neurotransmitter that promotes relaxation.7

Additionally, a recent study at the University of Catania, Italy found that Bacopa’s antioxidants have a protective effect on human DNA fibroblasts (connective tissue cells), suggesting that this Ayurvedic herb may be useful in the treatment of diseases in which free radicals play a key role.8 We all know that an optimal level of nitric oxide (NO) is important. This is because NO is a key mediator in many body functions, most notably cardiovascular health and circulation. However, like most good things, too much nitric oxide can be as dangerous as too little. There is growing evidence that excessive concentrations of nitric oxide (NO), generated within overly activated brain cells, might be involved in a variety of neurodegenerative diseases, such as Alzheimer’s disease and epilepsy. A rodent study of brain cells exposed to toxic levels of nitric oxide showed that Bacopa inhibited the DNA damage that occurs in these diseases, suggesting that it may be significant in preventing/or treating them.12

Ayurvedic texts describe three aspects of mental ability: dhi (the power of acquisition or learning), dhriti, (the power of retention), and smriti (the ability to recall). When the three mental functions are not in balance, either individually or in their coordination with one another, then learning problems can crop up. Children who have learning problems often feel like failures in school, which leads to frustration and low self-esteem.

When these three mental functions are coordinated, then the child’s memory is quick and bright. If impurities (ama) are obstructing the channels of communication between these three functions, then not only learning problems but behavioral problems can begin. The high incidence of Attention Deficit Hyperactivity Disorder (ADHD) in this country is a prime example of a learning/behavioral problem for millions of children. According to a study in Advanced Pediatrics, the frequency of ADHD among school children has been estimated to be as high as 20 percent.

To understand how Bacopa monniari can help nourish the memory and attention span in children, it’s important to understand the three subdoshas involved in memory. These are Prana Vata, which governs the brain, sensory perception, and the mind; Sadhaka Pitta, which governs the emotions and their effect on the functions of the heart; and Tarpaka Kapha, which governs the spinal fluids, sinus cavities, and sensory organs. In ayurveda, three types of imbalances of the mind are described, and each is associated with a different subdosha. We can correlate diminished learning ability combined with a hyperactive mind, with a breakdown in Prana Vata. A disturbance in Sadhaka Pitta is associated with a learning imbalance that carries over from childhood into adolescence and young adulthood — the Pitta time of life. And imbalances in Tarpaka Kapha correlate with problems with learning that occur without hyperactivity involved.

Two chemicals in bacopa, bacosides A and B, improve the transmission of impulses between nerve cells in your brain. These bacosides regenerate synapses and repair damaged neurons, making it easier for you to learn and remember new things. Bacopa also increases level of serotonin, a brain chemical known to promote relaxation. The herb’s ability to boost brain function while reducing anxiety may explain why it helps treat ADHD.

An unpublished double-blind study conducted in India in 1998 examined bacopa’s effects on 8- to 10-year-old children with ADHD. In it, 19 children took 100 mg of the herb daily while 17 took a placebo. After 12 weeks, those who used the herb performed significantly better on learning tests than the placebo group.

The texts mention that Brahmi is both medhya and hridya, meaning that it supports both the heart and the mind. A study in the Journal of Ethnopharmacology shows that Brahmi improved acquisition, retention and delayed extinction of newly acquired behavior in rats. Bacopa apparently provides a specialized cleansing and repair system for our nervous system. Its “memory chemicals” are unique saponins known as bacosides. Saponins are natural detergents present in many plants and are commonly used in soaps because of their foaming action. They help flush out damaging chemicals, such as free radicals and excess cholesterol, from the body, protecting molecules such as DNA from damage. The key ones in bacopa, bacoside A and B, are a mixture of saponins that further serve to repair damaged nerve cell connections by aiding protein synthesis, thereby allowing nerves to transmit signals more effectively. The bacosides, combined with many other chemicals in the plant — such as useful alkaloids, sterols and flavonoids — provide a well-stocked cache of brain and nerve foods to boost learning and memory.

The main feature of this ailment is a loss of nerve-cell function in the brain’s hippocampus, and animal studies indicate bacosides have antioxidant activity in the hippocampus as well as the frontal cortex and striatum. This suggests they may help protect the integrity of the brain’s nerve cells in these regions and perhaps deter the onset or development of the disease.

  1. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29(5):S359-65.
  2. Channa S, Dar A, Yaqoob M, Anjum S, Sultani Z, Atta-ur-Rahman. Bronchovasodilatory activity of fractions and pure constituents isolated from Bacopa monniera. J Ethnopharmacol. 2003 May; 86(1): 27-35
  3. Goel RK, Sairam K, Babu MD, Tavares IA, Raman A. In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine. 2003; 10(6-7): 523-7.
  4. Sairam K, Rao CV, Babu MD, Goel RK. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine. 2001 Nov; 8(6): 423-30.
  5. Negi KS, Singh YD, Kushwaha KP, Rastogi CK, Rathi AK, Srivastava JS, Asthana OP, Gupta RC, Lucknow G. “Clinical evaluation of memory enhancing properties of Memory Plus in children with Attention Deficit Hyperactivity Disorder.” Indian Journal of Psychiatry, 2000 Apr; 42(2) Supplement
  6. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001 Aug;156(4):481-4 7.
  7. Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3 – a triterpenoid saponin from Bacopa monniera. Phytochemistry 1994 May;36(1):133-7. Russo A, Izzo AA, Borrelli F, Renis M, Vanella A. Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother Res. 2003 Sep; 17(8): 870-5.
  8. Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (brahmi) extract on avoidance responses in the rat. J Ethnopharmacol 1982;5:205-14.
  9. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res. 2000 May; 14(3): 174-9.
  10. Singh RH, Singh L. Studies on the anti-anxiety effect of the medyha rasayana drug, Brahmi (Bacopa monniera Wettst). Part 1. J Res Ayur Siddha 1980;1:133-48.

Effect of Bacopa Monnieri on Cognitive Functions in Alzheimer’s Disease Patients


Background: Alzheimer’s disease is a degenerative condition mostly affecting the elderly. It significantly affects the patient’s quality of life. So far there is no proven effective therapeutic intervention for such patients. Bacopa monnieri is an indigenous plant which is found throughout India. It has been referred in Ayurveda since centuries as a “Medhya Rasayan” (nootropic).

Studies have shown various effects of Bacopa monnieri among which is its inhibitory effect on the enzyme cholinesterase. This can result in decrease in the breakdown of acetylcholine, an important neurotransmitter whose decreased levels are seen in Alzheimer’s disease.

Aims & Objectives:

We conducted this study to evaluate the effect of Bacopa monnieri on cognitive functions in Alzheimer’s disease patients.

Study Design:

This was an open label, prospective, uncontrolled, non-randomized trial. Study population included all newly diagnosed patients of Alzheimer’s disease in the Psychiatry Outdoor Patient Department between 60-65 years of age. Baseline scores on Mini Mental State Examination Scale (MMSES) were recorded for all patients. Subsequently all patients took 300 mg of Bacopa monnieri standardized extract (Bacognize®) orally twice a day for 6 months. MMSES scores were recorded again after the completion of study drug.


Mean age of 39 patients who completed the study was 65.23 years. Study patients showed statistically significant improvements in various components of MMSES including orientation of time, place & person, attention and in their language component in terms of reading, writing & comprehension at the end of trial. The patients involved in this trial also reported improvement in their quality of life, and decrease in the irritability and insomnia.


The results of our clinical trial show that Bacopa monnieri standardized extract (Bacognize® 300 mg twice a day orally) for 6 months results in improvement in some aspects of cognitive functions in geriatric patients suffering from Alzheimer’s disease. While the above results are encouraging given the improvement in cognitive functions in geriatric Alzheimer’s disease patients, further studies that include a control group are required to validate these results.

Javita (Energy + Mind)

A cup of Javita continues the tradition of great-tasting coffee, but it offers coffee lovers something more. We call it “coffee evolved”, a specialty brew that harnesses the health benefits, antioxidants, pick-me-ups and flavors of traditional coffee—but adds a kick. Our exclusive blend of estate-grown South American coffee is infused with nutrients from select herbs to give you MORE energy, MORE alertness, MORE clarity, MORE of what you’re looking for in your daily cup – and then some.

One cup of Javita coffee costs less and offers more than a cup of coffee from your corner coffee shop or fast food restaurant. Enjoyed hot or cold, Javita energy + mind coffee is all natural, Kosher-certified, and the great taste and on-the-go convenience will have you reaching for another cup!

Get a Boost

Billions of coffee lovers around the world reach for their morning cup to help jumpstart their day, and their brain in the process. Coffee lovers ourselves, we recognize this desirable quality, which is why we’ve infused the herb Bacopa Monnieri to give you more of what you want and expect from your coffee—brain boosting qualities. Why Bacopa Monnieri? It has a long history of use as a popular brain tonic to increased mental clarity, improved mental and brain functions, enhance clear thinking and support learning and memory.

Bacopa Monnieri

The bacosides (saponins) in Bacopa appear to play a protective role in the synaptic functions of the nerves of the hippocampus, the seat of memory. Nerve impulses are transmitted across the synapses (the gap between the neurons, over which impulses lead to their learning), and their degeneration is believed to contribute to impaired memory and cognition. Use of Bacopa is thus thought to improve learning skills andimpaired memory. Additional brain effects of Bacopa demonstrated in lab research include reduction of both anxiety and depression. Biochemically, these nervous system effects have been attributed to an enhancement of the effects of the neurotransmitters acetylcholine and, possibly serotonin or GABA.

So what is it about this perennial creeping plant that has neurologist so excited?

Perhaps it’s the purported retention qualities exhibited during a double-blind randomized placebo controlled research study in Australia at the University of Woolongong. Or the decreased rate of forgetting or newly acquired information, verbal learning rate and memory consolidation observed during a similar study reported in Neuropsychopharmachology.

Sharpen Up

When formulating our energy + mind blend, we infused an herb called centella asiatica (or gotu kola) to add something your tall cup fromStarbuck’s will never provide, mental clarity. Why gotu kola? It has been used as a medicinal herb for thousands of years in India, China and Indonesia toimprove mental clarity.

Gotu Kola

Gotu kola has been referred to as “food for the brain.” This oriental herb has demonstrated mild tranquilizing, anti-anxiety and anti-stress effects, as well as improving mental functions such as concentration and memory. It has a calming effect on the body and is chiefly used to support the central nervous system. These beneficial qualities offer some hope for those who have challenges focusing, as the herb has demonstrated the ability to have a soothing and relaxing effect on an overactive nervous system.

As a brain tonic, gotu kola is said to aid intelligence and memory. It strengthens the adrenal glands while cleansing the blood to treat skin impurities. It is said to combat stress and depression, energize flagging mental powers, increase libido, ward off a nervous breakdown and improve reflexes. It energizes the central nervous system and rebuilds energy reserves.

Click here to view the latest product testimonials.


An Unparalleled Cup of Energy + Mind

Five reasons to drink Energy + Mind:

1. You fall in love with the rich flavor of the estate-grown South American blend of Arabica and Robusta coffee beans.

2. The results (and lack of side effects) will keep you coming back for more.

3. Each single-serving packet is manufactured in the USA by a world-class, FDA compliant facility.

4. Tall, short, hot or cold—the options for enjoying your morning cup are as endless as your imagination.

5. It’s a great value. Where else can you enjoy a delicious, high-quality coffee PLUS proven memory-supportive, brain-enhancing nutrients for a little over $1 a cup?

No smarter or safer way to jumpstart your your morning and focus your mind than a delicious cup of energy+mind.

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