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Study: Breast cancer chemopreventive and chemotherapeutic effects of green tea

Introduction

Camellia sinensis belongs to the plant family of Theaceae, native to East Asia, the Indian Subcontinent and Southeast Asia, but naturalized in many parts of the world. The aim of this study was to overview its anti-breast cancer chemopreventive and chemotherapeutic effects. This review article is aimed to overview breast cancer chemopreventive and chemotherapeutic effects of Camellia sinensis (green tea).

Methods

This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified around 108 references. In this study, 68 studies were accepted for further screening, and met all our inclusion criteria [in English, full text, chemopreventive and chemotherapeutic effects of Camellia sinensis and dated mainly from the year 1999 to 2016. The search terms were Camellia sinensis, chemopreventive, chemotherapeutic properties, pharmacological effects.

Result

The result of this study suggested that the catechin available in Camellia sinensis has properties which can prevent and treat breast cancer. It has also been shown to inhibit proliferation of breast cancer cells and to block carcinogenesis. It was found that increased Camellia sinensis consumption may lower the risk of breast cancer. Camellia sinensis intake was shown to reduce the risk of breast cancer incidence. In addition, potential breast cancer chemopreventive effect of Camellia sinensis both in vivo and in vitro was highly confirmed.

Conclusion

Camellia sinensis is broadly utilized as a part of customary medication since antiquated time because of its cost adequacy, and fewer reaction properties. The studies demonstrated anti-breast cancer activity of Camellia sinensis and its component by adjusting cell signaling pathways such as angiogenesis, apoptosis, and transcription factor. Furthermore, Camellia sinensis and its chemical compound was shown to be extremely useful in the development of novel anticancer medications.

Click here to view the study in its entirety.

 


Roughing It: The Importance of Fiber Everyday

You hear it… You read it… Your doctor tells you eat more fiber, take more fiber, supplement with fiber. But do you really know why fiber is so important? Fiber reduces the risk of developing various conditions, including heart disease, diabetes, diverticular disease and constipation.

High intake of dietary fiber has been linked to lowering the risk of heart disease. In a Harvard study of over 40,000 male health professionals, researchers found that a high total dietary fiber intake was linked to a 40% lower risk of coronary heart disease, compared to a low fiber intake. Studies also indicate that a diet high in cereal fiber was linked to a lower rise of type 2 diabetes.

In North America, diverticulitis, an inflammation of the intestines (very painful), occurs in one-third of all those over the age of 45 and in two-thirds of those over age 85. Among male health professionals in a long-term follow up study, eating dietary fiber, particularly insoluble fiber, was associated with about 40% lower risk of diverticular disease.

Constipation is the most common gastrointestinal complaint in the U.S. The gastrointestinal tract is highly sensitive to dietary fiber, and consumption of fiber seems to relieve and reduce constipation.

The benefits of fiber are numerous, but getting enough is difficult. Be sure you’re getting yours through your diet and supplementation every day.

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SOURCES OF FIBER:

Soluble Fiber Insoluble Fiber
Oatmeal/ Oatbran Whole grain
Nuts & seeds Whole grain cereal
Legumes Wheat bran
Apples Seeds
Pears Carrots / celery
Strawberries Cucumbers / Zucchini
Blueberries Tomatoes

Ingredient Spotlight: ActiveBlendz Defend’s Elderberry Reduces Cold Duration and Symptoms

ABSTRACT:

Intercontinental air travel can be stressful, especially for respiratory health. Elderberries have been used traditionally, and in some observational and clinical studies, as supportive agents against the common cold and influenza. This randomized, double-blind placebo-controlled clinical trial of 312 economy class passengers travelling from Australia to an overseas destination aimed to investigate if a standardised membrane filtered elderberry (Sambucus nigra L.) extract has beneficial effects on physical, especially respiratory, and mental health. Cold episodes, cold duration and symptoms were noted in a daily diary and assessed using the Jackson score. Participants also completed three surveys containing questions regarding upper respiratory symptoms (WURSS-21) and quality of life (SF-12) at baseline, just before travel and at 4-days after travel. Most cold episodes occurred in the placebo group (17 vs. 12), however the difference was not significant (p = 0.4). Placebo group participants had a significantly longer duration of cold episode days (117 vs. 57, p = 0.02) and the average symptom score over these days was also significantly higher (583 vs. 247, p = 0.05). These data suggest a significant reduction of cold duration and severity in air travelers. More research is warranted to confirm this effect and to evaluate elderberry’s physical and mental health benefits.

Keywords: elderberry, travel, cold symptoms, clinical trial, nutritional supplements, complementary medicines, sambucus, physical health

Introduction

Air travel, especially on intercontinental flights can be stressful, thus putting extra strain on passenger’s physical and psychological health [1]. Studies have shown that passengers’ well-being is influenced by the cabin environment such as cabin ozone concentration and oxygen pressure, motion or vibration and oil additives used in aircraft engines [2,3]. Fatigue, impairment of immunity as well as increased stress and mental changes has been reported during and after long-distance flights [4,5,6]. A recent review of medical in-flight events lists respiratory symptoms among the most common medical complaints reported [7]. Not surprisingly, many studies have investigated the occurrence of nasal dryness and the increased risk of developing upper respiratory disorders such as allergic rhinitis and attracting virus or bacteria induced respiratory infections during long-haul air travel [8,9]. Moreover, an added risk of spreading respiratory diseases, including influenza, aboard commercial flights exists [10].

Recently, for the first time a herbal medicine, echinacea, was trialled in travellers and showed protective effect against the development of respiratory symptoms during travel involving long-haul flights [11]. Following travellers return from overseas, participants using echinacea displayed a lower respiratory symptom score and the overall percentage of participants affected by respiratory disease symptoms was marginally lower in the Echinacea group compared to placebo.

However, there are other herbs that have traditionally been used to treat respiratory symptoms and aid in the recuperation from a cold. Black elderberries for example, are well known to be supportive agents against common cold and flu like symptoms and have been used for centuries [12]. Interestingly, a non-travel related clinical trial just revealed that a combination of echinacea herb and root extract supplemented with elderberry (Sambucus nigra L.) can be as effective as the conventional antiviral medicine oseltamivir for the early treatment of influenza [13].

Elderberries have shown antibacterial [14] and antiviral activities in in vitro [15]. Two clinical trials using a liquid elderberry extract (Sambucol®, Israel) showed a reduction in symptoms and duration of influenza infection [16]. A pilot trial with elderberry extract lozenges (HerbalScience, Singapore) also confirmed a beneficial effect on severity and duration of cold and flu like symptoms [17].

In recent times, elderberry has gained popularity in research and the wider community due to its reported antioxidant [18], antidiabetic [19], anti-inflammatory and immune-modulating [20], as well as antidepressant [21] properties. The berries are dark violet-black drupes which grow in clusters and owe their colour to the anthocyanins; a group of phenolic compounds which, amongst flavonoids, are abundant in elderberries and considered the active constituents of the fruits [22]. However, elderberries also contain a variety of nutrients ranging from various vitamins (A, B1, B2, B6, B9, C and E), trace elements such as Cu, Zn, Fe and minerals such as K, Ca and Mg to phytochemicals such as carotenoids, phytosterols and polyphenols. These additional constituents and activities make elderberries a likely candidate for beneficial nutritional and/or medical supplementation not only for respiratory, but also for cardiovascular and mental health, all of which may be affected during travel.

Given that elderberry supplementation has never been investigated so far for its possible beneficial effects in air-travelers, we conducted a randomized controlled trial aimed at identifying whether capsules containing a proprietary membrane filtered Elderberry extract (Iprona, Italy), standardized to polyphenols, are effective in preventing respiratory symptoms, but also if they positively impact on the overall physical and mental health of travelers when using long-haul, commercial flights as means of transport.

Click here to read more about this published 2016 study.

 


Bacopa Monnieri and Epilepsy Study

ABSTRACT:

Bacopa monnieri is an outstanding nervine tonic used for raising the mental performance.

It helps in concentration, comprehension, recall and alertness, Brahmi is particularly beneficial as it aids in categorizing information in brain and its subsequent expression.

Bacopa is also called as a natural antioxidant which may give details its neuroprotective role seen in the memory centers of the brain.

Scientific research on B. monnieri revealed its anticonvulsant, antioxidant, memory and cognition improving properties.

These are transient behavioral abnormalities and cognitive impairments in epileptic patients.

During long-term treatment, epileptic drugs are creating cognitive and memory deficit in patients. B. monnieri can be used as a herbal medicine for ameliorating the memory and cognitive impairments during epilepsy.

The present review summarizes information concerning botany, chemistry and beneficial effect of Bacopa monnieri on epilepsy associated behavioral deficits.

Click to view the study in its entirety.


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