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Protect Your Joints from AutoImmune Attack

More than 52 million Americans suffer from some form of arthritis.

Conventional medical wisdom has long held that rheumatoid arthritis results from an autoimmune attack on joints, while osteoarthritis was thought to result from age-related “wear-and-tear.”

For the first time, a team of researchers at Stanford University has demonstrated that this is not true!

It turns out that osteoarthritis is accompanied by the same pathological, pro-inflammatory immune factors involved in rheumatoid arthritis. Even more compelling was their finding that, if treatment is initiated before symptoms manifest, osteoarthritis may be entirely prevented.

Unfortunately, the list of available drugs to combat autoimmune disorders—including long-term treatment with corticosteroids like prednisone—is notoriously limited and comes with life-threatening complications, including obesity and diabetes.

The exciting news is a novel intervention has been identified that safely regulates the immune system to protect aging joint tissue from autoimmune attacks.

In this article, you will learn about natural collagen concentrate (NCC). Its unique molecular characteristics prevent immune cells’ overreaction to proteins normally found in cartilage and joint tissue that lead to pain and stiffness in both rheumatoid and osteoarthritis.

In multiple clinical trials using this proprietary collagen formulation, scientists at Harvard have been able to achieve relief of arthritic symptoms, with some patients experiencing complete remission!

You will also learn how NCC’s mode of action may be synergistically enhanced when combined with Boswellia serrata and two other joint-renewing nutrients.

The Stanford team’s discovery of the autoimmune link between osteoarthritis and rheumatoid arthritis was first presented in late 2011.

A group of 25 scientists concluded that the development of osteoarthritis is in great part driven by low-grade inflammatory processes. Specifically, the researchers discovered that the body launches an orchestrated, powerful attack on the synovial joints via signaling proteins normally used to fight infections. This autoimmune response, they reported, plays a key role in osteoarthritis onset.

Synovial joints are the most common joint types in the human body. They contain soft-tissue cushioning in addition to cartilage, along with synovial fluid, a natural lubricant. Knees, hips, and shoulders are just a few of the commonly arthritic joints that fall into this category.

What the Stanford team found was that low-grade inflammation is not merely an early symptom of osteoarthritic cartilage destruction in synovial joints—it is the trigger that causes it. The study also revealed that by targeting the autoimmune derangements that occur early on in the development of osteoarthritis, arthritis might be completely preventable.

They went on to point out that drugs intended to inhibit the arthritic reaction (like corticosteroids) paradoxically compromise the immune system. It would be far safer, they reported, if a natural way to turn off the body’s abnormal response were available.

Novel Method to Target the Pathologic Immune Response

Here’s how it works.These compelling new findings coincided with the development of a naturalintervention shown to protect tissues in aging joints called undenatured type II collagen.

Joints are lined with cartilage that both lubricates joints and absorbs physical impacts, preserving ease of motion and comfort. The bulk of the cartilage in your joints consists of collagen, a biomolecular protein critical to reducing friction and keeping joints youthful.

Osteoarthritis and rheumatoid arthritis both involve the structural degradation and gradual destruction of cartilage in aging joints. Osteoarthritis was long thought to be a consequence of simple “wear- and-tear” on joints (and hence largely inevitable). Rheumatoid arthritis, on the other hand, was recognized as an inflammatory autoimmune disease that arises when the body mistakenly attacks its own tissues, in this case the joint linings and cartilage.

We now know that both arise from pro-inflammatory immune factors.

Intrinsic to this process is the mobilization of “killer” T-cells into the joints by exposed collagen within the synovial lining.

Under normal conditions, collagen elicits no immune response. It is exposed collagen that immune cells mistakenly identify as invasive, foreign molecules.7 In response to the “threat,” inflammatory cytokines are released that draw in more “killer” T-cells.13 Those cells bombard exposed cartilage with toxic chemicals in order to destroy it, creating oxidative stress and further inflammation in the process.

Over time, these continuous biomolecular insults erode and disintegrate the cartilage that lubricates and functions as a shock-absorber in joints.

The resulting pain can become chronic and debilitating in lockstep with sensations of friction or grinding involved in joint movement. While less acute at rest, this pain is exacerbated by walking, standing, or any form of weight-bearing. Osteoarthritis sufferers often experience joint stiffness or immobility after periods of inactivity, for instance upon waking or after a long period of sitting.

NCC® Triggers Specific Oral Tolerance for Lasting Joint Relief

In both osteoarthritis and rheumatoid arthritis, the chief cause of autoimmune response is exposed collagen and the ensuing attack by sensitized killer T-cells.

Suppose an effective means of regulating killer T-cells before they encountered exposed collagen could be developed? This would “re-train” them to treat exposed collagen as a harmless substance and prevent joint degradation and destruction.

In 2000, the first hint of just such an intervention emerged.

A team of scientists at the University of Nebraska was surprised to find that chicken soup prevented the mobilization of immune system cells to sites of inflammation. Upon further analysis, it was not vegetables but a soluble component of the chicken broth itself that exerted this anti-inflammatory activity.

The researchers believe that it was likely the collagen from chicken bones in the broth that was the source of this beneficial anti-inflammatory effect.

New Way to Combat Rheumatoid and Arthritis

  • The most common joint disease, osteoarthritis, was long viewed as a disease of wear-and-tear. New findings reveal that it is one of a number of disorders caused by an abnormal response of the immune system.
  • Instead of the traditionally prescribed NSAIDs and immune suppressants, a revolutionary and side effect-free form of undenatured type II collagen called NCC® has been shown to desensitize the immune system and prevent pro-inflammatory autoimmune attacks on aging joints.
  • Undenatured type II chicken collagen has been shown in studies to be capable of activating the pathway known as induced oral tolerance, which teaches the immune system to correctly recognize exposed cartilage proteins as the body’s own tissues—instead of foreign microbes—thus preventing an inflammatory attack, a newly recognized cause of osteoarthritis.
  • The anti-inflammatory action of a novel composition of AKBA-enriched Boswellia serrata—and two joint-protective nutrients, glucosamine sulfate and boron, now available in highly bioactive formulations—can further boost the ability of undenatured type II chicken collagen to fight osteoarthritis, the painful condition behind so many visits to primary care physicians. Owing to its particular molecular structure, the chicken-derived type II collagen in UC-II® acts as a kind of “reverse vaccine,” one that regulates the immune system so that it stops mobilizing attacks against proteins normally found in healthy joint cartilage.

It does so by inducing what immunologists call specific oral tolerance—the desensitization of immune response to specific agents via an orally administered intervention. This is why NCC® may be likened to a kind of oral vaccine that reverses T-cell attacks on exposed cartilage.

Scientists at Harvard first studied the effects of NCC® on human patients with rheumatoid arthritis, long established as an autoimmune disorder. In a randomized, double-blind trial of 60 patients, undenatured type II chicken collagen produced a significant decrease in the number of swollen and painful joints within 3 months, compared to the placebo group. In fact, 14% of patients achieved complete remission. No side effects were found.

Later, a much larger study of 274 rheumatoid arthritis patients confirmed this finding, as did a study on patients with juvenile rheumatoid arthritis, a particularly aggressive form of this disease.

Turning their attention to osteoarthritis, scientists tested undenatured type II collagen on horses and dogs. They noted a reduction of 88% in measurable pain among horses given this formulation. In one study, moderately arthritic dogs given the undenatured collagen formulation were able to place more weight on sore limbs, and use them more naturally, relative to those given placebo, or those given chondroitin plus glucosamine.

The gold standard of scientific evidence is a randomized, double-blind, clinical study on humans. In a study of this type involving 52 adult human volunteers with osteoarthritis, who had an average age of 59, scientists found that in just 90 days, undenatured type II chicken collagen produced “significant enhancement in daily activities suggesting an improvement in their quality of life.”

In this trial, using the standardized WOMAC (Western Ontario McMaster Osteoarthritis Index) scale, scientists found that 40 mg a day of undenatured type II chicken collagen reduced osteoarthritis symptoms by 33% in 90 days. By comparison, the combination of 1,500 mg a day of glucosamine and 1,200 mg a day of chondroitin sulfate reduced WOMAC scores by only 14%.

Pain scores on the visual analog scale (VAS) decreased 40% for the collagen group, while pain scores for the glucosamine/chondroitin group decreased just 15%.

Finally, using the Lequesne’s functional index score—which measures pain during daily activities, such as walking—the study team found that undenatured type II collagen reduced this score by 20%, while the combination of glucosamine and chondroitin lowered the score by only 6%. All results were observed in just 90 days.

Why Undenatured Type II Collagen

As discussed earlier, immune system T-cells are tasked with recognizing and distinguishing between “self” molecules and “foreign” ones. They do this important work by responding to very specific molecular shapes and 3-dimensional structures. If T-cells in the blood are simply exposed, without any “training,” to a previously unrecognized protein structure (such as those found on joint collagen) they react violently and trigger a massive inflammatory response to destroy the protein.

This is why, when scientists want to create an animal model of arthritis, they inject collagen into their subjects, sensitizing the T-cells in their blood to the protein. Those circulating T-cells set up inflammation in the animal’s joints, with their rich supplies of collagen.

If T-cells are given adequate preparation, however, they can be “taught” that a specific molecule is a friend rather than a foe. Where does such T-cell “training” take place?

In the intestinal tract, specifically the lower end of the small intestine, which is rich in collections of immune tissue called Peyer’s patches. Peyer’s patches act as “training centers” for T-cells, exposing them to all sorts of molecular shapes that are natural components of the food we eat. In that fashion, we desensitize our immune systems and develop a natural tolerance to new foods without having constant allergic or inflammatory reactions.

So, by providing native collagen of the right 3-dimensional structure to the digestive tract, rather than to the bloodstream directly, we can “educate” our T-cells to ignore collagen when they encounter it in joints. Scientists say that this enables people to develop oral tolerance to collagen.

And oral tolerance to collagen powerfully suppresses joint inflammation, as has been shown in numerous laboratory studies. Oral administration of soluble type II collagen even prevents arthritis induced experimentally by collagen injections.

But not just any collagen works. Typical commercial processing causes collagen to become denatured, uncoiling from its normal helical shape and losing its 3-dimensional structure. Denatured collagen has no beneficial effects on joint inflammation.

A more natural form of collagen, called undenatured type II collagen, or UC-II®, has recently been developed. UC-II® is a highly effective product and a rich source of natural collagen. UC-II® retains its original 3-dimensional molecular structure, keeping it recognizable by T-cells in Peyer’s patches. And UC-II is robust enough to survive the harsh conditions in the stomach and small intestine, arriving at Peyer’s patches with its molecules intact.

Neutralizing the Pro-inflammatory 5-LOX Enzyme

Incorporating a safe anti-inflammatory agent in a joint protection program may provide an additional layer of defense against arthritic damage and pain, by helping to eliminate the immune trigger.

In traditional Indian medicine, the gum resin of Boswellia serrata is associated with alleviating inflammatory diseases such as arthritis. Double-blind, placebo-controlled studies have shown boswellia decreases swelling and pain in patients with osteoarthritis of the knee.

Various compounds within boswellia exert an anti-inflammatory action that is different from most anti-inflammatory agents: they inhibit the pro-inflammatory enzyme 5-lipoxygenase or 5-LOX.

A highly bioactive boswellia compound—called 3-O-acetyl-11-keto-b-boswellic acid, or AKBA—directly binds to and selectively inhibits 5-LOX.21,22 This prevents 5-LOX from facilitating the production of leukotriene, a pro-inflammatory compound that damages cartilage and joints. AKBA also reduces pro-inflammatory leukocyte elastase activity. The problem up to now has been limited bioavailability of AKBA following oral administration.

Fortunately, researchers have developed a boswellia formulation with enhanced bioavailability. Scientists administering this patented boswellia compound to animals found that it increased the bioavailability of AKBA in the systemic circulation by 52%, compared with a standard boswellia extract.

The researchers concluded that the AKBA-rich boswellia product “consistently…confers better anti-inflammatory efficacy,” and “provides more potential benefits in recovering articular cartilage damage… due to inflammatory insult in arthritis such as osteoarthritis or rheumatoid arthritis.”

In a double-blind, randomized, placebo-controlled study on human patients with osteoarthritis, 100 mg of the patented AKBA-enriched boswellia extract inhibited the cartilage-degrading enzyme MMP-3, and exhibited an anti-inflammatory action that was superior to a standard boswellia extract. Benefits were seen as early in the 90-day study as 7 days. The journal-published report described the formulation as a “novel synergistic composition.”


Is Boswellia Serrata a Natural Cancer Fighter? MAYBE!

Cancer touches all of us in some form or fashion, and while there is no cure for it, research emerges everyday suggesting the incredible preventative and healing powers of botanicals.

Because it turns off reactions of the immune system that drive up inflammation and swelling, boswellia is considered a natural treatment for cancer and capable of fighting pain in addition to inflammation. Boswellia serrata extract is so powerful that today it’s considered comparable to NSAID pain relievers (the leading type of chemical anti-inflammatory medications).

However, unlike over-the-counter or prescription medications that come along with all sorts of side effects, boswellia extract has been used safely and without complications for thousands of years. The chemical structure of boswellic acids closely resemble those of steroids — however their actions are different and do much more than mask symptoms. (1)

Sound too good to be true? Let’s take a look at how boswellia can help curb your pain, clear up respiratory or sinus infections fast, treat inflammatory bowel disease, and even protect you from cancer.

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Lowers Inflammation

Among the valuable boswellia tree extracts that researchers have identified, several stand out as being most beneficial, including terpenes and boswellic acids, which are strongly anti-inflammatory and protective over healthy cells. Terpenes are strong-smelling chemicals found in certain plants, including some we associate with having antioxidant abilities, such as eucalyptus, basil, peppermint and citrus trees. (5)

Terpenes play a vital role in protecting the plants that contain them, since their strong aroma can fight off insect predators, defend plants from environmental stresses and act as building blocks for important chemical processes. In the human body, terpenes can do the same thing, lowering free radical damage and prolonging health.

Other chemical compounds have been identified in boswellia that naturally reduce the inflammatory response by controlling T-lymphocytes, especially one called AKBA (3-O-acetyl-11-keto-beta-boswellic acid). Although it works similarly to NSAID pain relievers, AKBA’s exact mechanisms of action are very different because they target different inflammatory enzymes. Because they’re better able to preserve the integrity of the stomach and gut lining, boswellia’s extracts cause less side effects and pose less risk for toxicity compared to NSAIDs. (6)

AKBA fights pain thanks in part to its ability to inhibit an enzyme called 5-LOX (5-lipoxygenase) and therefore shut down mechanisms of leukotrienes, which are inflammatory mediators produced by the process of oxidation (specifically of arachidonic acid). AKBA has shown to be effective against a large number of inflammatory diseases, such as arthritis, bronchial asthma, chronic colitis, ulcerative colitis, Crohn’s disease and cancer.

Another active component of boswellia is called incensole acetate, which has similar powers over lowering inflammatory reactions, especially those that target the brain and speed up cognitive decline. Studies show that incensole acetate is protective over neurons, fights the formation of tumors and has mood-enhancing benefits, making it a natural antidepressant and anti-anxiety compound.

Reduces Joint and Arthritis Pain

A study published in the Natural Medicines Comprehensive Database showed that boswellia extract can help reduce pain, swelling and trouble moving in people with arthritis or osteoarthritis (a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint) and other forms of inflamed joints. Some experienced a significant reduction in joint pain by up to 32 percent to 65 percent, which is comparable to prescription medications, showcasing boswellia’s ability as a natural arthritis treatment. (7)

Another study published in the Journal of Phytotherapy and Phytopharmacology found that boswellia treated osteoarthritis symptoms such as knee pain, knee jerking and pain while walking significantly better than treatment with a placebo. Researchers concluded that the anti-inflammatory, anti-arthritic and analgesic activities of boswellia make it a promising treatment for decreasing knee pain, increasing knee flexion and increasing walking distances in those prone to frequent swelling in the knee joints. (8)

Fights Cancer

Frankincense oil, which is formed by purifying the resin taken from the trunk of the boswellia tree, has been used for thousands of years medicinally, as well in religious and cultural ceremonies. Today, research tell us that frankincense essential oil is strongly tied to cancer prevention. Frankincense is taken by many people around the world with no known side effects. It effectively targets cancer cells while preserving healthy cells, which is why it’s used in conjunction with traditional cancer treatments by many holistic practitioners.

Research shows a link between AKBA and protection against brain, breast, colon, pancreatic, prostate and stomach cancers. The cancer-killing properties of boswellia extracts and frankincense oil are in part due to how they influence our genes to promote healing, plus how they curb serious side effects of cancer treatments. One of the most challenging and devastating things about battling cancer is suffering through the life-threatening and painful side effects that treatments like chemotherapy and radiation often cause, but boswellia shows promise for fighting these complications. (9)

For example, frankincense and boswellia extracts have been shown to fight joint pain, swelling in the brain, digestive complications and migraine headaches without destroying healthy cells that leave people vulnerable to infections. In addition to frankincense fighting cancer, it also supports the immune system in other ways by preventing infections, lowering inflammation, promoting hormonal balance, improving skin health and lowering anxiety (sometimes described as improving “spiritual awareness”).

Speeds Up Healing From Infections

Boswellia is capable of lowering severity of infections of the respiratory or sinus tracts, which means you can experience relief from coughing, colds, the flu or a sore throatfaster. Research shows boswellia also helps prevent allergies and asthma, eliminates phlegm in the lungs, and acts as an anti-inflammatory in the nasal passages, which makes it easier to breath.

In Traditional Chinese Medicine, frankincense has been used as a natural remedy for improving blood circulation, speeding up healing time and in relieving pain from a variety of bacterial or viral infections, such as colds or the flu, leprosy or gonorrhea. Studies also show that boswellia is a natural antiviral and can help treat strong and serious viruses, such as the flu or those caused by insect bites. (1011)

Prevents Autoimmune Disease

One of the oldest uses of frankincense oil and boswellia is treating a variety of auotimmune ailments, especially common inflammatory diseases including asthma, arthritis and chronic bowel diseases. Boswellia interferes with autoimmune disease development, since it seems to help control the production of immunoglobulins, or antibodies, which are made by the immune system to fight potential threats: bacteria, viruses, fungi and toxins.

The fact that boswellia has inhibitory actions that decrease production of leukotrienes has received high attention by researchers who study chronic inflammatory diseases that are rooted in increased leukotriene activity. As one study published in the International Journal of Phytotherapy and Phytopharmacology puts it, “At the end of the cascade of events in the cellular immune system, as far as it directs to various tissues of the body — i.e. autoimmune diseases — formation of oxygen radicals and proteases play an important destructive role … it’s not surprising that positive effects of boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn’s disease have been reported.” (12)

Your immune system constantly makes different types of antibodies to fight off various diseases (or “antigens“), but sometimes this process goes wrong and antibodies can actually be created that fight your very own bodily tissue, including healthy tissue that forms your organs. When this takes place, autoimmune disease occurs, which can affect nearly every system within the body.

Many studies have shown that boswellia helps treat inflammatory bowel diseases (IBD) including ulcerative colitis, Crohn’s disease and collagenous colitis. IBS is a term for a group of intestinal disorders that cause prolonged inflammation of the digestive tract, especially the bowel lining that’s important for normal nutrient absorption and waste elimination. IBS can also affect other parts of the digestive system, including the mouth, esophagus, stomach, and small and large intestines. Research shows that leukotrienes play a large role in igniting inflammation that disrupts normal bowel function.

Boswellia helps patients enter remission from IBS since it reduces inflammation/swelling associated with bowel diseases, restores normal bowel cell structures, improves stool properties significantly, and helps heal openings in the bowel wall. One study published in the European Journal of Medical Research found that 350 milligrams of boswellia extract given three times daily for six weeks resulted in patients experiencing improvements in all parameters tested. A whopping 82 percent of IBD patients went into remission, which was even more than the percentage of patients who were using the standard prescription for IBD called sulfasalazine! (13)

Similarly, supplementation with boswellia has been shown to be effective for facilitating remission in patients with collagenous colitis, another type of IBD that causes abdominal pain, rectal bleeding, diarrhea and lots of discomfort. In a study done by the Department of Medicine at Medical College Jammu in India, boswellic acids were found to inhibit the enzyme 5-lipoxygenase, which is a major contributor to the disease. Twenty patients were given boswellia serrata (900 milligrams daily divided in three doses for six weeks), and at the end of the trial, 18 out of 20 patients showed an improvement in one or more of the parameters tested while 14 out of 20 went into remission. (14)

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Boswellin is golden gift of flex to fitness enthusiasts everywhere

Boswellin is key to reducing inflammation

Boswellia serrata, also known as the Indian version of frankincense, used for thousands of years for its ability to manage inflammatory disorders.

Over the last few years, boswellia has attracted much attention in the world medical community because it possesses anti-inflammatory properties that are equal to prescription medications without the unpleasant/dangerous side effects.

For example, research conducted in India found that, amongst ailments cured by an extract of boswellia, arthritis (rheumatoid) was dramatically relieved–considering its less toxic and more potent than the standard drug of choice at the time, benzoyl hydrotropic acid.

How It Works

Boswellia works through entirely different mechanisms than anti-inflammatory drugs. Whereas most drugs function as Cox enzyme inhibitors, boswellia works by inhibiting lipoxygenase enzymes (LOX), which are powerful contributors to inflammation and disease. By inhibiting LOX enzymes, boswellia effectively blocks leukotriene synthesis. Leukotrienes play a major role in promoting a whole host of age-associated, inflammation-related diseases including joint problems, intestinal disorders, cancer, and lung related disease.

In addition, it appears that boswellia can inhibit the breakdown of connective tissues caused by tumor necrosis factor-alpha, a potent inflammatory agent in the body.

And finally, it appears that boswellia has the ability to modulate the immune system and inhibit inflammatory activity, thereby helping with a number of autoimmune conditions, including rheumatoid arthritis.

Or to put it in simpler terms, the boswellic acids in boswellia seem to have the ability to suppress the proliferating tissue found in inflamed areas of the body and prevent the concomitant breakdown of connective tissue. In addition, boswellia has been found to improve blood supply to the joints and restore the integrity of weakened blood vessels, again with no side effects as seen with the traditional drugs of choice.


The Secret to Flex’s Pain Relief & Product Reviews

Boswellia (boswellia serrata) is a tree gum resin that has multiple health benefits. Also known as frankincense, it has been burned as incense in religious and cultural ceremonies for centuries.  In today’s alternative health world boswellia is widely regarded as a potent anti-inflammatory nutrient, wherein its primary active ingredient, acetyl-11-keto-β-boswellic acid (AKBA), inhibits the inflammatory enzyme 5-lipoxygenase.  Excess 5-lipoxygenase is common in joint pain, allergies, respiratory conditions, and cardiovascular problems.  A number of new studies give insights into boswellia, a unique nutrient, even expanding its potential usefulness.

Pain relief / inflammation

Managing pain and inflammation without the adverse side effects of prescription and OTC drugs is one of the great advantages of nutrition. The standardized extracts of Boswellia—an herb with a long medicinal history—offers one of the top choices in this regard. A human clinical trial with knee osteoarthritis confirms the benefits of Boswellia for joint health. Another study confirms its ability to disband problematic germ gangs. A number of studies demonstrate its anti-inflammatory benefits in a variety of health situations.

The knee osteoarthritis study was a double blind, randomized, placebo controlled 90-day study involving 60 people. It tested two different standardized Boswellia extracts, both of which were found to produce statistically significant improvement in pain and joint mobility. The association of joint pain and obesity is a common finding.  Researchers now know that it isn’t just the extra weight causing mechanical wear and tear.  There appear to be common inflammation mechanisms causing both joint destruction and obesity.  One emerging culprit is excessive amounts of lipopolysaccharide (LPS).  LPS is generated as bacteria sheath off their outer wall.  Overweight individuals typically have imbalanced digestive bacteria making larger-than-normal amounts of LPS, which enter the general circulation and trigger inflammation, including joint inflammation.  Another new study shows that boswellia can directly attach itself to toxic LPS, preventing the LPS from doing anything inflammatory.  This is a novel way that boswellia reduces inflammation and is of particular value for individuals who are overweight and experiencing joint pain.

Diabetes

We are now in an epidemic of type 2 diabetes.  Interestingly, many people who persist in this condition also develop type 1 diabetes, because their pancreas gets too inflamed and tired out from having to try to make insulin all the time.  Another recent study shows that boswellia was able to prevent the rise in blood sugar due to toxin-induced type 1 diabetes.  Boswellia protected the insulin producing cells in the pancreas from damage.  It reduced a number of inflammatory messages, including two of the most common that are elevated when a person is overweight (IL-6 and TNFa).  This study supports the idea that boswellia can help protect the pancreas.

Liver Health

In an animal experiment of intentionally induced free radical damage, boswellia reduced the amount of damage in the liver by 80 percent and in the heart by 50 percent.  The researchers demonstrated potent anticoagulant properties, significantly reducing platelet aggregation. Preventing your blood from getting too sticky is vital to healthy circulation and stroke prevention. Boswellia not only lowers factors in your blood that promote stickiness, but it also has a direct impact on the rate of clotting.  In this study it extended the prothrombin time on par with heparin. This study supports the use of boswellia as part of your blood health team.

Cellular Health

One of the hot topics in cancer research is the subject of epigenetics. Epigenetics deals with the topic of how genes are expressed, rather than a true genetic malfunction based on a change to the DNA sequence. Researchers studying epigenetics now realize the power of environment and nutrition to influence gene function and thus cancer risk.  New research shows that boswellia is another nutrient that can influence epigenetic function.  Working with colon cancer cells researchers found that boswellia changed epigenetic function so that tumor suppressor genes started functioning again.

Boswellia has been shown to reduce inflammation and free radical damage. Specifically, it is shown to reduce inflammatory nitric oxide (iNOS), thereby helping asthma sufferers improve their health. In patients undergoing radiation therapy for brain tumors, boswellia significantly reduced inflammatory swelling and edema in the brain . Inflammatory processes typically promote the spreading of cancer. Researchers at the MD Anderson Cancer Center found that Boswellia deactivates the key receptor on cancer cells (pancreatic and breast cancer cells were tested) that allows the cancer to spread and invade. Another recent study on mice with implanted tumors found that Boswellia reduced tumor size and increased survival time. A detailed analysis of the Boswellia-treated tumors showed that Boswellia activated gene signals that caused tumor cell death. The researchers concluded, “The present study sheds light on the potent antitumor property of the boswellic acid and can be extended further to develop therapeutic protocols for treatment of cancer.”

45708229_lACTIVEBLENDZ FLEX PRODUCT REVIEWS

Checkout some of the reviews Flex is earning from Customers and Member’s alike, thanks in part due to the pain-relieving, anti-inflammatory attributes of this incredible herb:

“One morning, unbeknownst to my husband, who has arthritis in his hands, I gave him FLEX in his GREEN TEA. I wanted to see if he noticed any improvement. At the end of the day he asked me if what he was drinking addressed joints because his hands weren’t as painful as usual. These were same day results!! Needless to say, he wants FLEX every morning now. He is a believer and likes to tell others what it does for him! So thankful for FLEX and the other products that have benefited our lives.” Brenda Niles Bolen

“I shared a box of Javita Flex with my mom about 6 weeks ago. She had knee surgery a few years back and still was in pain everyday. She loved the flavor ( strawberry lemonade) so she drank a packet everyday. I did a follow up with her this past week. She told me that her knee pain is much more bearable and she has more flexibility. The best news of all was when she said she cut back on her pain medication!! Thank you Javita for another great product.” Brenda Niles Bolen

“About three years ago I was diagnosed with psoriatic arthritis after noticing pain in some of my finger joints. As custom, I was prescribed medication. I have issues with my lower back (great for the golf game) and a separated shoulder as well. In the last 30+ days, I’ve been adding “Flex” to my water instead of an on-the-go packet. Currently I’m experiencing little to no pain in each designated location; substituting one flavor for another. Could this be any easier? NO!” David Trouse

“I have been suffering from osteoarthritis for the past 4 years .. The pain I have is mainly in my hips, knees and my hands depending on the weather these areas will flare up .. when I drink my FLEX the inflammation in the joints go down quite a bit, since I take a blood thinner my medication is limited this is why drinking FLEX works wonders for me… Thank you Javita!” Cheri DeVarennes

“I recently had a MRI that showed disc on nerve and I was barely able to walk for 2 weeks due to pain. I also have severe neuropathy from Cancer treatment. I began drinking Flex as soon as it came out. I am happy to say I am walking better and feel pain free! Thank you Javita for the research that went into Flex!” Lisa Hughes

“I absolutely LOVE this product !!! All our Activeblendz have great benefits.. I started drinking the flex the day it was released and I found from just 1 a day my body has totally loosened up and taken away 10 years of stiffening joints! When I use to wake up in the morning it took me a good 15 minutes to be completely mobile from my ankles, knees, hips etc,, now I wake up have a great stretch from head to toe and am ready to go, no more cracking and slowly moving. Thank you Javita, Flex really works and I love it.” Melanie Molleken

“My husband played college basketball till he suffered knee & joint pain years ago. Coupled with his profession as a Manager Sushi Chef, better days are rare as far as shoulder, knee & joint pain are concerned.Pain relievers, massage oils, elevation can only do little relief & I felt helpless watching my husband go through the daily grind with this condition.When FLEX became a part of his daily beverage, I personally noticed a HUGE change! It’s been a month since he started playing ball again, this time with our boys. To quote my man, “My shoulder pain & ‘clicking’ knee sound are gone, discomfort is gone, overall no more pain.. I can now play basketball again, my life is back!” FLEX works!” Katherine Michelle D. Alvarado

“I had ACL reconstructive surgery on my right knee over a 1 year and a half ago, I had torn my ACL in half. Always had inflammation problems and stiff joint. Started drinking the Flex and it was answer to my prayers!! No more Ibuprofen needed! Knee therapy going smooth back at the gym and cycling! No more pain, no more stuff joint! So happy!! Just turned 49 feeling 25!! #flex Cynthia Bañuelos

“My Mom just had surgery, she had a tumor on her left kidney so her doctors had to remove 1/3 of her kidney. It was caused by using insulin for more than 30years. Before her surgery she started having Sciatica so the only advise was to go thru therapy or take painkillers, however it didn’t help her much. After her surgery it was hard for her to move, because of her cut and giving her ibuprofen or painkillers was risky because it might be bad for her kidneys. What I did was give her Activeblendz Flex. After a week of using it, 2 sachets a day, she feels good. No more pain and no need to go thru therapy! Now she’s down to 1 sachet a day. I just saved a fortune on all therapies that wasn’t really helping Mom. Thanks Javita!” Joey Gruet


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